InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NMNAT1

Summary

InnateDB Protein

IDBP-685007.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NMNAT1

Protein Name

Nicotinamide mononucleotide adenylyltransferase 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000048652

InnateDB Gene

IDBG-633313 (NMNAT1)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity
GO:0003824	catalytic activity
GO:0004515	nicotinate-nucleotide adenylyltransferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0016779	nucleotidyltransferase activity

Biological Process

GO:0009058	biosynthetic process
GO:0009435	NAD biosynthetic process
GO:0019363	pyridine nucleotide biosynthetic process

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR004821 Cytidyltransferase-like domain
IPR005248 Probable nicotinate-nucleotide adenylyltransferase

PFAM

PF01467

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0VD50

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

522863

UniGene

Bt.59388

RefSeq

NP_001069302

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC119834

GenPept

AAI19835