Version 5.4
Bos taurus Protein: CTNNBIP1
Summary
InnateDB Protein IDBP-685009.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTNNBIP1
Protein Name Beta-catenin-interacting protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000007790
InnateDB Gene IDBG-633315 (CTNNBIP1)
Protein Structure
UniProt Annotation
Function Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0070016 armadillo repeat domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0002528 regulation of vascular permeability involved in acute inflammatory response
GO:0009952 anterior/posterior pattern specification
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0031333 negative regulation of protein complex assembly
GO:0032091 negative regulation of protein binding
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045657 positive regulation of monocyte differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter
GO:0072201 negative regulation of mesenchymal cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030877 beta-catenin destruction complex
Protein Structure and Domains
PDB ID
InterPro IPR009428 Beta-catenin-interacting ICAT
PFAM PF06384
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9N2
PhosphoSite PhosphoSite-
TrEMBL B0JYK9
UniProt Splice Variant
Entrez Gene 785901
UniGene
RefSeq NP_001032219
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151327 BT020888
GenPept AAI51328 AAX08905

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca