InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LYVE1

Summary

InnateDB Protein

IDBP-685010.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LYVE1

Protein Name

Lymphatic vessel endothelial hyaluronic acid receptor 1

Synonyms

CRSBP-1; LYVE-1; XLKD1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001061

InnateDB Gene

IDBG-633316 (LYVE1)

Protein Structure

UniProt Annotation

Function

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. {ECO:0000269PubMed:12912978}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans- Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005540	hyaluronic acid binding

Biological Process

GO:0006027	glycosaminoglycan catabolic process
GO:0006810	transport
GO:0007155	cell adhesion
GO:0007165	signal transduction

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

InterPro

IPR000538 Link
IPR016187 C-type lectin fold

PFAM

PF00193

PRINTS

PR01265

PIRSF

SMART

SM00445

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6UC88

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

404179

UniGene

Bt.24189

RefSeq

NP_991384

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY372937

GenPept

AAQ85130