InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ATP6V1E2

Summary

InnateDB Protein

IDBP-685016.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1E2

Protein Name

V-type proton ATPase subunit E 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000018250

InnateDB Gene

IDBG-633322 (ATP6V1E2)

Protein Structure

UniProt Annotation

Function

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport

Cellular Component

GO:0001669	acrosomal vesicle
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain

Protein Structure and Domains

PDB ID

InterPro

IPR002842 ATPase, V1/A1 complex, subunit E

PFAM

PF01991

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q32LB7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

540113

UniGene

Bt.50607

RefSeq

NP_001073081

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC109658

GenPept

AAI09659