Version 5.4
Bos taurus Protein: CTSS
Summary
InnateDB Protein IDBP-685036.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSS
Protein Name Cathepsin S
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022774
InnateDB Gene IDBG-633332 (CTSS)
Protein Structure
UniProt Annotation
Function Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
Subcellular Localization Lysosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0043236 laminin binding
GO:0043394 proteoglycan binding
Biological Process
GO:0002250 adaptive immune response
GO:0006508 proteolysis
GO:0030574 collagen catabolic process
GO:0034769 basement membrane disassembly
GO:0050729 positive regulation of inflammatory response
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0097067 cellular response to thyroid hormone stimulus
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR000668 Peptidase C1A, papain C-terminal
IPR013201 Proteinase inhibitor I29, cathepsin propeptide
PFAM PF00112
PF08246
PRINTS PR00705
PIRSF
SMART SM00645
SM00848
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P25326
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 327711
UniGene Bt.7938
RefSeq NP_001028787
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102245 M95211 X62001
GenPept AAA30435 AAI02246 CAA43971

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca