Version 5.4
Bos taurus Protein: HORMAD1
Summary
InnateDB Protein IDBP-685040.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HORMAD1
Protein Name HORMA domain-containing protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003529
InnateDB Gene IDBG-633342 (HORMAD1)
Protein Structure
UniProt Annotation
Function Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-376 is restricted to unsynapsed chromosomal regions (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001824 blastocyst development
GO:0007126 meiotic nuclear division
GO:0007130 synaptonemal complex assembly
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0042138 meiotic DNA double-strand break formation
GO:0048477 oogenesis
GO:0051177 meiotic sister chromatid cohesion
GO:0051598 meiotic recombination checkpoint
GO:0060629 regulation of homologous chromosome segregation
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005694 chromosome
Protein Structure and Domains
PDB ID
InterPro IPR003511 DNA-binding HORMA
PFAM PF02301
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KIY6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 529615
UniGene Bt.108680
RefSeq NP_001039770
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03030055 BC112460
GenPept AAI12461

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca