InnateDB Protein
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IDBP-68505.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LLGL2
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Protein Name
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lethal giant larvae homolog 2 (Drosophila)
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Synonyms
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HGL; LGL2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364375
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InnateDB Gene
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IDBG-68503 (LLGL2)
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Protein Structure
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Function |
Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269PubMed:15632202}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:15632202}. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 300 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
300
[view]
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Protein-Protein |
300
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000664
Lethal(2) giant larvae protein
IPR013577
Lethal giant larvae homologue 2
IPR017986
WD40-repeat-containing domain
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PFAM |
PF08366
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PRINTS |
PR00962
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6P1M3
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PhosphoSite |
PhosphoSite-Q6P1M3
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TrEMBL |
J3QSA6
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UniProt Splice Variant |
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Entrez Gene |
3993
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UniGene |
Hs.514477
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RefSeq |
NP_001015002
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HUGO |
HGNC:6629
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OMIM |
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CCDS |
CCDS45776
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HPRD |
10041
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IMGT |
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EMBL |
AC100787
BC006503
BC010879
BC064994
X87342
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GenPept |
AAH06503
AAH10879
AAH64994
CAA60780
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