InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CTGF

Summary

InnateDB Protein

IDBP-685050.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTGF

Protein Name

Connective tissue growth factor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008357

InnateDB Gene

IDBG-633353 (CTGF)

Protein Structure

UniProt Annotation

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}. Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0008201	heparin binding

Biological Process

GO:0001502	cartilage condensation
GO:0001503	ossification
GO:0001525	angiogenesis
GO:0001558	regulation of cell growth
GO:0001894	tissue homeostasis
GO:0006260	DNA replication
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010629	negative regulation of gene expression
GO:0016477	cell migration
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0032330	regulation of chondrocyte differentiation
GO:0035988	chondrocyte proliferation
GO:0045597	positive regulation of cell differentiation
GO:0046330	positive regulation of JNK cascade
GO:0051496	positive regulation of stress fiber assembly
GO:0061448	connective tissue development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005794	Golgi apparatus
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR000884 Thrombospondin, type 1 repeat
IPR001007 von Willebrand factor, type C
IPR006207 Cystine knot, C-terminal
IPR006208 Glycoprotein hormone subunit beta, cystine knot
IPR012395 IGFBP-related, CNN

PFAM

PF00219
PF00090
PF00093
PF00007

PRINTS

PIRSF

PIRSF036495

SMART

SM00121
SM00209
SM00214
SM00041

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt