Version 5.4
Bos taurus Protein: ADCYAP1R1
Summary
InnateDB Protein IDBP-685086.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCYAP1R1
Protein Name Pituitary adenylate cyclase-activating polypeptide type I receptor
Synonyms PACAPR;
Species Bos taurus
Ensembl Protein ENSBTAP00000026333
InnateDB Gene IDBG-633373 (ADCYAP1R1)
Protein Structure
UniProt Annotation
Function This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004999 vasoactive intestinal polypeptide receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000832 GPCR, family 2, secretin-like
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR002285 GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
IPR017981 GPCR, family 2-like
PFAM PF00002
PF02793
PRINTS PR00249
PR01156
PIRSF
SMART SM00008
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q29627
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 319095
UniGene
RefSeq NP_783646
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL D17290
GenPept BAA04122 BAA04123

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca