Version 5.4
Bos taurus Protein: AQP1
Summary
InnateDB Protein IDBP-685121.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AQP1
Protein Name Aquaporin-1
Synonyms AQP-1; CHIP29;
Species Bos taurus
Ensembl Protein ENSBTAP00000000993
InnateDB Gene IDBG-633410 (AQP1)
Protein Structure
UniProt Annotation
Function Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005223 intracellular cGMP activated cation channel activity
GO:0005267 potassium channel activity
GO:0005372 water transmembrane transporter activity
GO:0005515 protein binding
GO:0008519 ammonium transmembrane transporter activity
GO:0015079 potassium ion transmembrane transporter activity
GO:0015168 glycerol transmembrane transporter activity
GO:0015250 water channel activity
GO:0022857 transmembrane transporter activity
GO:0030184 nitric oxide transmembrane transporter activity
GO:0035379 carbon dioxide transmembrane transporter activity
GO:0046875 ephrin receptor binding
Biological Process
GO:0003094 glomerular filtration
GO:0003097 renal water transport
GO:0006182 cGMP biosynthetic process
GO:0006810 transport
GO:0006813 potassium ion transport
GO:0006833 water transport
GO:0006884 cell volume homeostasis
GO:0015670 carbon dioxide transport
GO:0015696 ammonium transport
GO:0015793 glycerol transport
GO:0019233 sensory perception of pain
GO:0019725 cellular homeostasis
GO:0021670 lateral ventricle development
GO:0030104 water homeostasis
GO:0030157 pancreatic juice secretion
GO:0030185 nitric oxide transport
GO:0030335 positive regulation of cell migration
GO:0030950 establishment or maintenance of actin cytoskeleton polarity
GO:0032940 secretion by cell
GO:0033326 cerebrospinal fluid secretion
GO:0033363 secretory granule organization
GO:0033554 cellular response to stress
GO:0034644 cellular response to UV
GO:0035377 transepithelial water transport
GO:0035378 carbon dioxide transmembrane transport
GO:0042060 wound healing
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044241 lipid digestion
GO:0045766 positive regulation of angiogenesis
GO:0046878 positive regulation of saliva secretion
GO:0048146 positive regulation of fibroblast proliferation
GO:0048593 camera-type eye morphogenesis
GO:0050891 multicellular organismal water homeostasis
GO:0051458 corticotropin secretion
GO:0070295 renal water absorption
GO:0070301 cellular response to hydrogen peroxide
GO:0071241 cellular response to inorganic substance
GO:0071260 cellular response to mechanical stimulus
GO:0071280 cellular response to copper ion
GO:0071288 cellular response to mercury ion
GO:0071300 cellular response to retinoic acid
GO:0071320 cellular response to cAMP
GO:0071456 cellular response to hypoxia
GO:0071472 cellular response to salt stress
GO:0071474 cellular hyperosmotic response
GO:0071549 cellular response to dexamethasone stimulus
GO:0071732 cellular response to nitric oxide
GO:0071805 potassium ion transmembrane transport
GO:0072220 metanephric descending thin limb development
GO:0072230 metanephric proximal straight tubule development
GO:0072232 metanephric proximal convoluted tubule segment 2 development
GO:0072239 metanephric glomerulus vasculature development
GO:0072488 ammonium transmembrane transport
GO:0085018 maintenance of symbiont-containing vacuole by host
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0020003 symbiont-containing vacuole
GO:0020005 symbiont-containing vacuole membrane
GO:0030424 axon
GO:0031526 brush border membrane
GO:0031965 nuclear membrane
GO:0032127 dense core granule membrane
GO:0042383 sarcolemma
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000425 Major intrinsic protein
IPR023271 Aquaporin-like
IPR023274 Aquaporin 1
PFAM PF00230
PRINTS PR00783
PR02013
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P47865
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282653
UniGene Bt.65916
RefSeq NP_777127
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF028005 BC105525 BT025412 S74759
GenPept AAB32365 AAB84190 AAI05526 ABF57368

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca