InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PEBP1

Summary

InnateDB Protein

IDBP-685183.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PEBP1

Protein Name

Phosphatidylethanolamine-binding protein 1Hippocampal cholinergic neurostimulating peptide

Synonyms

PBP; PEBP;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000024107

InnateDB Gene

IDBG-633467 (PEBP1)

Protein Structure

UniProt Annotation

Function

Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). {ECO:0000250}.HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008289	lipid binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0030414	peptidase inhibitor activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0010466	negative regulation of peptidase activity
GO:0010951	negative regulation of endopeptidase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR008914 Phosphatidylethanolamine-binding protein PEBP

PFAM

PF01161

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13696

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

431786

UniGene

Bt.70654

RefSeq

NP_001028795

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102389

GenPept

AAI02390