Version 5.4
Bos taurus Protein: TCF21
Summary
InnateDB Protein IDBP-685184.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCF21
Protein Name Transcription factor 21
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000029098
InnateDB Gene IDBG-633474 (TCF21)
Protein Structure
UniProt Annotation
Function Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042826 histone deacetylase binding
GO:0043425 bHLH transcription factor binding
GO:0046983 protein dimerization activity
GO:0050681 androgen receptor binding
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001944 vasculature development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007530 sex determination
GO:0007548 sex differentiation
GO:0009887 organ morphogenesis
GO:0014707 branchiomeric skeletal muscle development
GO:0030855 epithelial cell differentiation
GO:0032835 glomerulus development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048286 lung alveolus development
GO:0048536 spleen development
GO:0048557 embryonic digestive tract morphogenesis
GO:0048608 reproductive structure development
GO:0048732 gland development
GO:0060008 Sertoli cell differentiation
GO:0060021 palate development
GO:0060425 lung morphogenesis
GO:0060426 lung vasculature development
GO:0060435 bronchiole development
GO:0060539 diaphragm development
GO:0060541 respiratory system development
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0072162 metanephric mesenchymal cell differentiation
GO:0072277 metanephric glomerular capillary formation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9S3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510873
UniGene Bt.5219
RefSeq NP_001014899
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105574 BT020847
GenPept AAI05575 AAX08864

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca