Version 5.4
Bos taurus Protein: RHBDF1
Summary
InnateDB Protein IDBP-685195.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHBDF1
Protein Name Inactive rhomboid protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000026388
InnateDB Gene IDBG-633479 (RHBDF1)
Protein Structure
UniProt Annotation
Function Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly localized in the endoplasmic reticulum membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0019838 growth factor binding
Biological Process
GO:0006508 proteolysis
GO:0006810 transport
GO:0008283 cell proliferation
GO:0015031 protein transport
GO:0016477 cell migration
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0061136 regulation of proteasomal protein catabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR022241 Rhomboid serine protease
IPR022764 Peptidase S54, rhomboid domain
PFAM PF12595
PF01694
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A7YWH9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 529167
UniGene Bt.30661
RefSeq NP_001098870
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134588
GenPept AAI34589

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca