InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NPR2

Summary

InnateDB Protein

IDBP-685223.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPR2

Protein Name

Atrial natriuretic peptide receptor 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015204

InnateDB Gene

IDBG-633504 (NPR2)

Protein Structure

UniProt Annotation

Function

Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004383	guanylate cyclase activity
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016829	lyase activity
GO:0016849	phosphorus-oxygen lyase activity
GO:0016941	natriuretic peptide receptor activity
GO:0042802	identical protein binding

Biological Process

GO:0001503	ossification
GO:0006182	cGMP biosynthetic process
GO:0006468	protein phosphorylation
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001170 Natriuretic peptide receptor
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001828 Extracellular ligand-binding receptor
IPR011009 Protein kinase-like domain
IPR028082 Periplasmic binding protein-like I

PFAM

PF00069
PF07714
PF01094

PRINTS

PR00255
PR00109

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P46197