Version 5.4
Homo sapiens Protein: TMEM129
Summary
InnateDB Protein IDBP-6853.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM129
Protein Name transmembrane protein 129
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000372394
InnateDB Gene IDBG-6851 (TMEM129)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation. {ECO:0000269PubMed:24807418}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:24807418}; Multi-pass membrane protein {ECO:0000269PubMed:24807418}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR018801 Putative transmembrane protein precursor
PFAM PF10272
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A0AVI4
PhosphoSite PhosphoSite-A0AVI4
TrEMBL
UniProt Splice Variant
Entrez Gene 92305
UniGene Hs.518562
RefSeq NP_001120738
HUGO HGNC:25137
OMIM
CCDS CCDS46998
HPRD 14290
IMGT
EMBL AC016773 BC009331 BC126370 CH471131
GenPept AAI26371 EAW82569 EAW82570 EAW82571

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca