InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SKAP2

Summary

InnateDB Protein

IDBP-685326.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SKAP2

Protein Name

Src kinase-associated phosphoprotein 2

Synonyms

SCAP2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000043366

InnateDB Gene

IDBG-633609 (SKAP2)

Protein Structure

UniProt Annotation

Function

May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0008285	negative regulation of cell proliferation
GO:0042113	B cell activation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR011511 Variant SH3 domain

PFAM

PF00018
PF14604
PF00169
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00326
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q32LP7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

616545

UniGene

Bt.19807

RefSeq

NP_001033303

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC109480

GenPept

AAI09481