Version 5.4
Bos taurus Protein: SNX10
Summary
InnateDB Protein IDBP-685334.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX10
Protein Name Sorting nexin-10
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002383
InnateDB Gene IDBG-633616 (SNX10)
Protein Structure
UniProt Annotation
Function Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=May also localize to nucleus and endoplasmic reticulum. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005545 1-phosphatidylinositol binding
GO:0008289 lipid binding
GO:0035091 phosphatidylinositol binding
GO:0051117 ATPase binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0007032 endosome organization
GO:0015031 protein transport
GO:0030030 cell projection organization
GO:0030316 osteoclast differentiation
GO:0042384 cilium assembly
GO:0061512 protein localization to cilium
GO:0071539 protein localization to centrosome
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0031313 extrinsic component of endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR001683 Phox homologous domain
PFAM PF00787
PRINTS
PIRSF
SMART SM00312
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0IIL5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508836
UniGene Bt.27822
RefSeq NP_001068843
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122586
GenPept AAI22587

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca