Version 5.4
Bos taurus Protein: AXIN1
Summary
InnateDB Protein IDBP-685401.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AXIN1
Protein Name axin 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022053
InnateDB Gene IDBG-633677 (AXIN1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.
Predicted by orthology
Total 72 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0032947 protein complex scaffold
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043621 protein self-association
GO:0046332 SMAD binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0001701 in utero embryonic development
GO:0001932 regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0006913 nucleocytoplasmic transport
GO:0007275 multicellular organismal development
GO:0007605 sensory perception of sound
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0009950 dorsal/ventral axis specification
GO:0016055 Wnt signaling pathway
GO:0030163 protein catabolic process
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031122 cytoplasmic microtubule organization
GO:0031398 positive regulation of protein ubiquitination
GO:0032147 activation of protein kinase activity
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0035412 regulation of catenin import into nucleus
GO:0036342 post-anal tail morphogenesis
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043507 positive regulation of JUN kinase activity
GO:0043623 cellular protein complex assembly
GO:0045599 negative regulation of fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0048318 axial mesoderm development
GO:0048320 axial mesoderm formation
GO:0051248 negative regulation of protein metabolic process
GO:0051260 protein homooligomerization
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0060070 canonical Wnt signaling pathway
GO:0071514 genetic imprinting
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005881 cytoplasmic microtubule
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016328 lateral plasma membrane
GO:0030877 beta-catenin destruction complex
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
GO:0071944 cell periphery
Protein Structure and Domains
PDB ID
InterPro IPR000342 Regulator of G protein signalling domain
IPR001158 DIX domain
IPR014936 Axin beta-catenin binding
IPR016137 Regulator of G protein signalling superfamily
PFAM PF00615
PF00778
PF08833
PRINTS PR01301
PIRSF
SMART SM00021
SM00315
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1B714
UniProt Splice Variant
Entrez Gene 504357
UniGene Bt.21602
RefSeq NP_001178327
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057275 GJ062847
GenPept DAA15676

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca