Version 5.4
Bos taurus Protein: CITED2
Summary
InnateDB Protein IDBP-685548.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CITED2
Protein Name Cbp/p300-interacting transactivator 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014907
InnateDB Gene IDBG-633814 (CITED2)
Protein Structure
UniProt Annotation
Function Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.
Subcellular Localization Nucleus {ECO:0000250}. Note=Colocalizes with EP300 in dot-like structures. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0035035 histone acetyltransferase binding
GO:0046332 SMAD binding
GO:0050693 LBD domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001829 trophectodermal cell differentiation
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0001944 vasculature development
GO:0001947 heart looping
GO:0002089 lens morphogenesis in camera-type eye
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002521 leukocyte differentiation
GO:0003151 outflow tract morphogenesis
GO:0003156 regulation of organ formation
GO:0003197 endocardial cushion development
GO:0003281 ventricular septum development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0007368 determination of left/right symmetry
GO:0007417 central nervous system development
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0007530 sex determination
GO:0008283 cell proliferation
GO:0008584 male gonad development
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0021602 cranial nerve morphogenesis
GO:0022409 positive regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0030325 adrenal gland development
GO:0030336 negative regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030851 granulocyte differentiation
GO:0034405 response to fluid shear stress
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035802 adrenal cortex formation
GO:0035914 skeletal muscle cell differentiation
GO:0043066 negative regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046697 decidualization
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048821 erythrocyte development
GO:0060136 embryonic process involved in female pregnancy
GO:0060349 bone morphogenesis
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060971 embryonic heart tube left/right pattern formation
GO:0061156 pulmonary artery morphogenesis
GO:0061308 cardiac neural crest cell development involved in heart development
GO:0061371 determination of heart left/right asymmetry
GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070986 left/right axis specification
GO:1900164 nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:2000020 positive regulation of male gonad development
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007576 CITED
PFAM PF04487
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VCT9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 521378
UniGene Bt.21607
RefSeq NP_001069287
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120010
GenPept AAI20011

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca