Bos taurus Protein: NOL9
Summary
InnateDB Protein IDBP-685552.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOL9
Protein Name Polynucleotide 5'-hydroxyl-kinase NOL9
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022240
InnateDB Gene IDBG-633805 (NOL9)
Protein Structure
UniProt Annotation
Function Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Colocalizes with pre-60S rRNP particles. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0051731 polynucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0000460 maturation of 5.8S rRNA
GO:0006364 rRNA processing
GO:0016310 phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR010655 Pre-mRNA cleavage complex II Clp1
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029007 MobB-type P-loop domain
PFAM PF06807
PF03205
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt E1BPN0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 523474
UniGene Bt.103226
RefSeq NP_001193528
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03030715
GenPept