Version 5.4
Bos taurus Protein: NEU1
Summary
InnateDB Protein IDBP-685565.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEU1
Protein Name Sialidase-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000007454
InnateDB Gene IDBG-633826 (NEU1)
Protein Structure
UniProt Annotation
Function Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage (By similarity). {ECO:0000250}.
Subcellular Localization Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}. Lysosome lumen {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004308 exo-alpha-sialidase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0052794 exo-alpha-(2->3)-sialidase activity
GO:0052795 exo-alpha-(2->6)-sialidase activity
GO:0052796 exo-alpha-(2->8)-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0009313 oligosaccharide catabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR011040 Sialidases
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6BMK7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 505554
UniGene Bt.12399
RefSeq NP_001077111
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB327106 AY937242 BC134571
GenPept AAI34572 AAX14675 BAF64705

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca