InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NGFRAP1

Summary

InnateDB Protein

IDBP-685582.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NGFRAP1

Protein Name

Protein BEX3

Synonyms

BEX3; WBP5;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000007916

InnateDB Gene

IDBG-633850 (NGFRAP1)

Protein Structure

UniProt Annotation

Function

May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005123	death receptor binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR007623 Brain-expressed X-linked protein
IPR021156 Transcription elongation factor A-like/Brain expressed X-linked-like

PFAM

PF04538

PRINTS

PIRSF

PIRSF008633

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3ZBJ6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

100034674

UniGene

Bt.49620

RefSeq

NP_001157249

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103258

GenPept

AAI03259