Version 5.4
Bos taurus Protein: TMOD1
Summary
InnateDB Protein IDBP-685602.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMOD1
Protein Name Tropomodulin-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000019585
InnateDB Gene IDBG-633864 (TMOD1)
Protein Structure
UniProt Annotation
Function Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005523 tropomyosin binding
Biological Process
GO:0006936 muscle contraction
GO:0008344 adult locomotory behavior
GO:0030239 myofibril assembly
GO:0051694 pointed-end actin filament capping
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0008180 COP9 signalosome
GO:0016020 membrane
GO:0030016 myofibril
GO:0030863 cortical cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR004934 Tropomodulin
PFAM PF03250
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A0JNC0
PhosphoSite PhosphoSite-
TrEMBL G1K1R3
UniProt Splice Variant
Entrez Gene 780784
UniGene Bt.105520
RefSeq NP_001073108
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126605 DAAA02023244 DAAA02023245 DAAA02023246
GenPept AAI26606

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca