Version 5.4
Bos taurus Protein: CARKD
Summary
InnateDB Protein IDBP-685686.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARKD
Protein Name carbohydrate kinase domain containing
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015238
InnateDB Gene IDBG-633902 (CARKD)
Protein Structure
UniProt Annotation
Function Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. {ECO:0000255HAMAP-Rule:MF_03157}.
Subcellular Localization Mitochondrion {ECO:0000255HAMAP- Rule:MF_03157}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0016829 lyase activity
GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity
Biological Process
GO:0046496 nicotinamide nucleotide metabolic process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR000631 YjeF C-terminal domain
IPR029056 Ribokinase-like
PFAM PF01256
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt E1BNQ4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 613996
UniGene Bt.20699
RefSeq XP_002692037
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02034911 DAAA02034912
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca