Version 5.4
Bos taurus Protein: SERPINA5
Summary
InnateDB Protein IDBP-685795.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINA5
Protein Name Plasma serine protease inhibitor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000005307
InnateDB Gene IDBG-634042 (SERPINA5)
Protein Structure
UniProt Annotation
Function Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary- type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space {ECO:0000250}. Note=Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed strongly in the liver, and moderately in the kidney and testis, but not in other tissues tested. {ECO:0000269PubMed:10739384}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0002020 protease binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0030414 peptidase inhibitor activity
GO:0031210 phosphatidylcholine binding
GO:0032190 acrosin binding
Biological Process
GO:0006810 transport
GO:0006869 lipid transport
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0002080 acrosomal membrane
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0031091 platelet alpha granule
GO:0031094 platelet dense tubular network
GO:0036024 protein C inhibitor-TMPRSS7 complex
GO:0036025 protein C inhibitor-TMPRSS11E complex
GO:0036026 protein C inhibitor-PLAT complex
GO:0036027 protein C inhibitor-PLAU complex
GO:0036028 protein C inhibitor-thrombin complex
GO:0036029 protein C inhibitor-KLK3 complex
GO:0036030 protein C inhibitor-plasma kallikrein complex
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0097181 protein C inhibitor-coagulation factor V complex
GO:0097182 protein C inhibitor-coagulation factor Xa complex
GO:0097183 protein C inhibitor-coagulation factor XI complex
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9N2I2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 338050
UniGene Bt.2712
RefSeq NP_788819
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB026444 BC109553 BT030731
GenPept AAI09554 ABS45047 BAA93451

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca