InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ARHGEF7

Summary

InnateDB Protein

IDBP-685829.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF7

Protein Name

Rho guanine nucleotide exchange factor (GEF) 7

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000027619

InnateDB Gene

IDBG-633975 (ARHGEF7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0030032	lamellipodium assembly
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0030027	lamellipodium
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001452 SH3 domain
IPR001715 Calponin homology domain
IPR001849 Pleckstrin homology domain
IPR011511 Variant SH3 domain

PFAM

PF00621
PF00018
PF14604
PF00307
PF00169
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00325
SM00326
SM00033
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt