InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PTPN11

Summary

InnateDB Protein

IDBP-685947.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN11

Protein Name

protein tyrosine phosphatase, non-receptor type 11

Synonyms

SHP2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002653

InnateDB Gene

IDBG-634172 (PTPN11)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 121 interaction(s) predicted by orthology.

Predicted by orthology
Total	121 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity
GO:0005070	SH3/SH2 adaptor activity
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0030971	receptor tyrosine kinase binding
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000187	activation of MAPK activity
GO:0006470	protein dephosphorylation
GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0007229	integrin-mediated signaling pathway
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0007507	heart development
GO:0009755	hormone-mediated signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0016311	dephosphorylation
GO:0030220	platelet formation
GO:0033277	abortive mitotic cell cycle
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0033629	negative regulation of cell adhesion mediated by integrin
GO:0035265	organ growth
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0035855	megakaryocyte development
GO:0036302	atrioventricular canal development
GO:0038127	ERBB signaling pathway
GO:0040014	regulation of multicellular organism growth
GO:0042445	hormone metabolic process
GO:0042593	glucose homeostasis
GO:0046676	negative regulation of insulin secretion
GO:0046825	regulation of protein export from nucleus
GO:0046887	positive regulation of hormone secretion
GO:0046888	negative regulation of hormone secretion
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048013	ephrin receptor signaling pathway
GO:0048609	multicellular organismal reproductive process
GO:0048806	genitalia development
GO:0048839	inner ear development
GO:0051463	negative regulation of cortisol secretion
GO:0060125	negative regulation of growth hormone secretion
GO:0060325	face morphogenesis
GO:2001275	positive regulation of glucose import in response to insulin stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR000980 SH2 domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00017
PF14633

PRINTS

PR00700
PR00401

PIRSF

PIRSF000929

SMART

SM00194
SM00252
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References