InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: STX17

Summary

InnateDB Protein

IDBP-685953.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STX17

Protein Name

Syntaxin-17

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010541

InnateDB Gene

IDBG-634187 (STX17)

Protein Structure

UniProt Annotation

Function

SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Smooth endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Has an hairpin-like insertion into membranes. Localized into endoplasmic reticulum membranes, it also localizes to the completed autophagosome membrane upon cell starvation. May also localize to the mitochondria. A significant amount is also present in the cytosol (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005484	SNAP receptor activity
GO:0005515	protein binding
GO:0019903	protein phosphatase binding

Biological Process

GO:0000046	autophagic vacuole fusion
GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006914	autophagy
GO:0007030	Golgi organization
GO:0016192	vesicle-mediated transport
GO:0097111	endoplasmic reticulum-Golgi intermediate compartment organization

Cellular Component

GO:0000421	autophagic vacuole membrane
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005829	cytosol
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030134	ER to Golgi transport vesicle
GO:0030868	smooth endoplasmic reticulum membrane
GO:0031201	SNARE complex
GO:0031410	cytoplasmic vesicle
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000727 Target SNARE coiled-coil domain
IPR010989 t-SNARE

PFAM

PF05739

PRINTS

PIRSF

SMART

SM00397

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5E9Y2

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

534304

UniGene

Bt.89222

RefSeq

NP_001029778

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123853 BT020788

GenPept

AAI23854 AAX08805