InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HMGCS2

Summary

InnateDB Protein

IDBP-686008.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGCS2

Protein Name

Hydroxymethylglutaryl-CoA synthase, mitochondrial

Synonyms

hmgCoA;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005088

InnateDB Gene

IDBG-634246 (HMGCS2)

Protein Structure

UniProt Annotation

Function

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004421	hydroxymethylglutaryl-CoA synthase activity
GO:0016740	transferase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0008152	metabolic process
GO:0008202	steroid metabolic process
GO:0008203	cholesterol metabolic process
GO:0008299	isoprenoid biosynthetic process
GO:0016126	sterol biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane

Protein Structure and Domains

PDB ID

InterPro

IPR010122 Hydroxymethylglutaryl-CoA synthase, eukaryotic
IPR013528 Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
IPR013746 Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
IPR016039 Thiolase-like

PFAM

PF01154
PF08540

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KIE6

PhosphoSite