InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PHGDH

Summary

InnateDB Protein

IDBP-686010.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHGDH

Protein Name

D-3-phosphoglycerate dehydrogenase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008907

InnateDB Gene

IDBG-634247 (PHGDH)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004617	phosphoglycerate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0048037	cofactor binding
GO:0051287	NAD binding

Biological Process

GO:0006541	glutamine metabolic process
GO:0006544	glycine metabolic process
GO:0006563	L-serine metabolic process
GO:0006564	L-serine biosynthetic process
GO:0006566	threonine metabolic process
GO:0008152	metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0009448	gamma-aminobutyric acid metabolic process
GO:0010468	regulation of gene expression
GO:0019530	taurine metabolic process
GO:0021510	spinal cord development
GO:0021782	glial cell development
GO:0021915	neural tube development
GO:0022008	neurogenesis
GO:0031175	neuron projection development
GO:0055114	oxidation-reduction process
GO:0070314	G1 to G0 transition

Cellular Component

GO:0070062

extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
IPR006236 D-3-phosphoglycerate dehydrogenase
IPR029009 Allosteric substrate binding domain

PFAM

PF00389
PF02826

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5EAD2

PhosphoSite