InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CAND1

Summary

InnateDB Protein

IDBP-686026.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAND1

Protein Name

Cullin-associated NEDD8-dissociated protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013112

InnateDB Gene

IDBG-634252 (CAND1)

Protein Structure

UniProt Annotation

Function

Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 546 interaction(s) predicted by orthology.

Predicted by orthology
Total	546 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0010265	SCF complex assembly
GO:0016567	protein ubiquitination
GO:0030154	cell differentiation
GO:0043086	negative regulation of catalytic activity

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0031461	cullin-RING ubiquitin ligase complex
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000357 HEAT
IPR013932 TATA-binding protein interacting (TIP20)
IPR016024 Armadillo-type fold

PFAM

PF02985
PF08623

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A7MBJ5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

538086

UniGene

Bt.2513

RefSeq

NP_001094643

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC151594

GenPept

AAI51595