Version 5.4
Bos taurus Protein: HES1
Summary
InnateDB Protein IDBP-686096.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HES1
Protein Name Transcription factor HES-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000742
InnateDB Gene IDBG-634294 (HES1)
Protein Structure
UniProt Annotation
Function Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00380, ECO:0000255PROSITE-ProRule:PRU00981}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
GO:0071820 N-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006461 protein complex assembly
GO:0007262 STAT protein import into nucleus
GO:0021861 forebrain radial glial cell differentiation
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043388 positive regulation of DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046427 positive regulation of JAK-STAT cascade
GO:0048711 positive regulation of astrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0060253 negative regulation of glial cell proliferation
GO:2000974 negative regulation of pro-B cell differentiation
GO:2000978 negative regulation of forebrain neuron differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR003650 Orange
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR018352 Orange subgroup
PFAM PF07527
PF00010
PRINTS
PIRSF
SMART SM00353
SM00511
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZBG4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 539547
UniGene Bt.49417
RefSeq NP_001029850
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103309
GenPept AAI03310

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca