InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: F10

Summary

InnateDB Protein

IDBP-686097.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F10

Protein Name

Coagulation factor XFactor X light chainFactor X heavy chainActivated factor Xa heavy chain

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021789

InnateDB Gene

IDBG-634314 (F10)

Protein Structure

UniProt Annotation

Function

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0007599	hemostasis
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR001881 EGF-like calcium-binding domain
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z

PFAM

PF00594
PF00008
PF00089
PF07645

PRINTS

PR00001
PR00722

PIRSF

PIRSF001143

SMART

SM00069
SM00181
SM00020
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References