InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PAPOLA

Summary

InnateDB Protein

IDBP-686114.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAPOLA

Protein Name

Poly(A) polymerase alpha

Synonyms

PAPOLB;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005300

InnateDB Gene

IDBG-634303 (PAPOLA)

Protein Structure

UniProt Annotation

Function

Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269PubMed:9463383}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17172643}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0003723	RNA binding
GO:0004652	polynucleotide adenylyltransferase activity
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0016779	nucleotidyltransferase activity
GO:0030145	manganese ion binding
GO:0046872	metal ion binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006369	termination of RNA polymerase II transcription
GO:0006378	mRNA polyadenylation
GO:0006397	mRNA processing
GO:0031123	RNA 3'-end processing
GO:0043631	RNA polyadenylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002934 Nucleotidyl transferase domain
IPR007010 Poly(A) polymerase, RNA-binding domain
IPR007012 Poly(A) polymerase, central domain
IPR011068 Nucleotidyltransferase, class I, C-terminal-like
IPR014492 Poly(A) polymerase

PFAM

PF01909
PF04926
PF04928

PRINTS

PIRSF

PIRSF018425

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25500

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

338051

UniGene

RefSeq

NP_788820

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

X61585 X63436

GenPept

CAA43782 CAA45031