Version 5.4
Bos taurus Protein: GNPTG
Summary
InnateDB Protein IDBP-686167.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNPTG
Protein Name N-acetylglucosamine-1-phosphotransferase subunit gamma
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000018766
InnateDB Gene IDBG-634384 (GNPTG)
Protein Structure
UniProt Annotation
Function Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine- 1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}. Golgi apparatus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016740 transferase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0008152 metabolic process
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR009011 Mannose-6-phosphate receptor binding domain
IPR012913 Glucosidase II beta subunit-like
PFAM PF07915
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58CS8
PhosphoSite PhosphoSite-
TrEMBL M5FJT7
UniProt Splice Variant
Entrez Gene 508713
UniGene Bt.64893
RefSeq NP_001017428
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142266 BT021869 GJ062847
GenPept AAI42267 AAX46716 DAA15559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca