InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CLCN7

Summary

InnateDB Protein

IDBP-686269.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLCN7

Protein Name

H(+)/Cl(-) exchange transporter 7

Synonyms

CLC-7; CLC7;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021122

InnateDB Gene

IDBG-634451 (CLCN7)

Protein Structure

UniProt Annotation

Function

Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen (By similarity). {ECO:0000250}.

Subcellular Localization

Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005216	ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015297	antiporter activity
GO:0030554	adenyl nucleotide binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0034220	ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000644 CBS domain
IPR001807 Chloride channel, voltage gated
IPR002249 Chloride channel ClC-7
IPR014743 Chloride channel, core

PFAM

PF00571
PF00654

PRINTS

PR00762
PR01118

PIRSF

SMART

SM00116

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q4PKH3

PhosphoSite

PhosphoSite-

TrEMBL

M5FKE3

UniProt Splice Variant

Entrez Gene

513545

UniGene

Bt.6124

RefSeq

NP_001020502

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DQ073465 GJ062847

GenPept

AAY82470 DAA15577