InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CLDN16

Summary

InnateDB Protein

IDBP-686296.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLDN16

Protein Name

Claudin-16

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008509

InnateDB Gene

IDBG-634511 (CLDN16)

Protein Structure

UniProt Annotation

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Disease Associations

Note=Defects in CLDN16 are a cause of an autosomal recessive chronic interstitial nephritis with diffuse zonal fibrosis (CINF). CINF is characterized by increased blood urea nitrogen, creatinine, and urinary proteins, leads to lethality before puberty, usually within the first 6 months or year of life.

Tissue Specificity

Expressed preferentially in kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0016338	calcium-independent cell-cell adhesion

Cellular Component

GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

InterPro

IPR003927 Claudin-16
IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR006187 Claudin

PFAM

PF00822
PF13903

PRINTS

PR01447
PR01077

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9XT98

PhosphoSite

PhosphoSite-

TrEMBL

Q9TUF7

UniProt Splice Variant

Entrez Gene

282184

UniGene

Bt.483

RefSeq

NP_776944

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB030082 AB035210

GenPept

BAA82553 BAA87045