Version 5.4
Bos taurus Protein: WWP2
Summary
InnateDB Protein IDBP-686391.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WWP2
Protein Name NEDD4-like E3 ubiquitin-protein ligase WWP2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024513
InnateDB Gene IDBG-634611 (WWP2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016874 ligase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0010629 negative regulation of gene expression
GO:0016567 protein ubiquitination
GO:0032410 negative regulation of transporter activity
GO:0034765 regulation of ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051224 negative regulation of protein transport
GO:0051865 protein autoubiquitination
GO:0070534 protein K63-linked ubiquitination
GO:1901016 regulation of potassium ion transmembrane transporter activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR000569 HECT
IPR001202 WW domain
PFAM PF00168
PF00632
PF00397
PRINTS PR00360
PIRSF
SMART SM00239
SM00119
SM00456
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A3KMV3
UniProt Splice Variant
Entrez Gene 512457
UniGene Bt.102981
RefSeq NP_001076883
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133288 DAAA02046708 DAAA02046709 JN712753
GenPept AAI33289 AFK29262

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca