Version 5.4
Bos taurus Protein: WARS
Summary
InnateDB Protein IDBP-686418.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WARS
Protein Name Tryptophanyl-tRNA synthetase, cytoplasmicT1-TrpRST2-TrpRS
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006139
InnateDB Gene IDBG-634635 (WARS)
Protein Structure
UniProt Annotation
Function T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2- TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004830 tryptophan-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006436 tryptophanyl-tRNA aminoacylation
GO:0045765 regulation of angiogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000738 WHEP-TRS
IPR002305 Aminoacyl-tRNA synthetase, class Ic
IPR002306 Tryptophan-tRNA ligase
IPR009068 S15/NS1, RNA-binding
PFAM PF00458
PF00579
PRINTS PR01039
PIRSF
SMART SM00991
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P17248
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281576
UniGene Bt.43956
RefSeq NP_776643
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102806 X52113 X53918
GenPept AAI02807 CAA36356 CAA37872

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca