Version 5.4
Bos taurus Protein: TRIM21
Summary
InnateDB Protein IDBP-686459.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM21
Protein Name E3 ubiquitin-protein ligase TRIM21
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000054004
InnateDB Gene IDBG-634640 (TRIM21)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006513 protein monoubiquitination
GO:0031648 protein destabilization
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032897 negative regulation of viral transcription
GO:0045087 innate immune response
GO:0045787 positive regulation of cell cycle
GO:0046598 positive regulation of viral entry into host cell
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051865 protein autoubiquitination
GO:0070206 protein trimerization
GO:0090086 negative regulation of protein deubiquitination
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0019005 SCF ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018957 Zinc finger, C3HC4 RING-type
IPR020457 Zinc finger, B-box, chordata
PFAM PF00643
PF13639
PF14634
PF00622
PF13765
PF00097
PRINTS PR01407
PR01406
PIRSF
SMART SM00336
SM00184
SM00449
SM00589
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3MWU8
UniProt Splice Variant
Entrez Gene 359715
UniGene Bt.72714
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02040968 DAAA02040969 DAAA02040970
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca