Version 5.4
Bos taurus Protein: TRIM21
Summary
InnateDB Protein IDBP-686461.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM21
Protein Name E3 ubiquitin-protein ligase TRIM21
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000018459
InnateDB Gene IDBG-634640 (TRIM21)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)- like complex is shown to mediate ubiquitination of CDKN1B ('Thr- 187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin- mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Note=Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 in P-body (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006513 protein monoubiquitination
GO:0007049 cell cycle
GO:0016567 protein ubiquitination
GO:0031648 protein destabilization
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0045787 positive regulation of cell cycle
GO:0051865 protein autoubiquitination
GO:0090086 negative regulation of protein deubiquitination
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0019005 SCF ubiquitin ligase complex
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID
InterPro IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018957 Zinc finger, C3HC4 RING-type
IPR020457 Zinc finger, B-box, chordata
PFAM PF00643
PF13639
PF14634
PF00622
PF13765
PF00097
PRINTS PR01407
PR01406
PIRSF
SMART SM00336
SM00184
SM00449
SM00589
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7YRV4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 359715
UniGene Bt.72714
RefSeq NP_872596
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY312278 BC123700 BT021885
GenPept AAI23701 AAP79314 AAX46732

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca