InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DNAJB11

Summary

InnateDB Protein

IDBP-686470.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJB11

Protein Name

DnaJ homolog subfamily B member 11

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004094

InnateDB Gene

IDBG-634686 (DNAJB11)

Protein Structure

UniProt Annotation

Function

Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0016556	mRNA modification

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001623 DnaJ domain
IPR002939 Chaperone DnaJ, C-terminal
IPR008971 HSP40/DnaJ peptide-binding

PFAM

PF00226
PF01556

PRINTS

PR00625

PIRSF

SMART

SM00271

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3ZBA6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

506316

UniGene

Bt.49533

RefSeq

NP_001029440

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103470

GenPept

AAI03471