Version 5.4
Bos taurus Protein: BT.25712
Summary
InnateDB Protein IDBP-686484.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.25712
Protein Name Alpha-tubulin N-acetyltransferase
Synonyms C23H6orf134; MEC17; TAT;
Species Bos taurus
Ensembl Protein ENSBTAP00000009133
InnateDB Gene IDBG-634651 (BT.25712)
Protein Structure
UniProt Annotation
Function Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Required for normal sperm flagellar function. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255HAMAP-Rule:MF_03130}.
Subcellular Localization Cytoplasm {ECO:0000255HAMAP-Rule:MF_03130}. Membrane, clathrin-coated pit {ECO:0000255HAMAP-Rule:MF_03130}. Cell junction, focal adhesion {ECO:0000255HAMAP-Rule:MF_03130}. Cell projection, axon {ECO:0000255HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton {ECO:0000255HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton, spindle {ECO:0000255HAMAP- Rule:MF_03130}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0019799 tubulin N-acetyltransferase activity
Biological Process
GO:0048666 neuron development
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071929 alpha-tubulin acetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005905 coated pit
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0042995 cell projection
Protein Structure and Domains
PDB ID
InterPro IPR007965 Alpha-tubulin N-acetyltransferase
IPR016181 Acyl-CoA N-acyltransferase
PFAM PF05301
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58CX6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 786491
UniGene Bt.25712
RefSeq XP_005223746
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142375 BT021821
GenPept AAI42376 AAX46668

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca