InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PGAP2

Summary

InnateDB Protein

IDBP-686497.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGAP2

Protein Name

Post-GPI attachment to proteins factor 2

Synonyms

FRAG1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011097

InnateDB Gene

IDBG-634715 (PGAP2)

Protein Structure

UniProt Annotation

Function

Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0006506	GPI anchor biosynthetic process
GO:0006974	cellular response to DNA damage stimulus
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0015031	protein transport
GO:0042770	signal transduction in response to DNA damage
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR019402 Frag1/DRAM/Sfk1

PFAM

PF10277

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6H7B8

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

540520

UniGene

Bt.59210

RefSeq

NP_001092581

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC146186

GenPept

AAI46187