InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TRA2B

Summary

InnateDB Protein

IDBP-686543.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRA2B

Protein Name

Transformer-2 protein homolog beta

Synonyms

SFRS10;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002225

InnateDB Gene

IDBG-634751 (TRA2B)

Protein Structure

UniProt Annotation

Function

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0048026	positive regulation of mRNA splicing, via spliceosome

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain

PFAM

PF00076

PRINTS

PIRSF

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3ZBT6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

615156

UniGene

Bt.49333

RefSeq

NP_001029948

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103113

GenPept

AAI03114