Version 5.4
Bos taurus Protein: HES5
Summary
InnateDB Protein IDBP-686557.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HES5
Protein Name transcription factor HES-5
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003221
InnateDB Gene IDBG-634771 (HES5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006461 protein complex assembly
GO:0007155 cell adhesion
GO:0007219 Notch signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007420 brain development
GO:0008284 positive regulation of cell proliferation
GO:0014003 oligodendrocyte development
GO:0021537 telencephalon development
GO:0021781 glial cell fate commitment
GO:0021915 neural tube development
GO:0022010 central nervous system myelination
GO:0030513 positive regulation of BMP signaling pathway
GO:0031641 regulation of myelination
GO:0042491 auditory receptor cell differentiation
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042668 auditory receptor cell fate determination
GO:0043010 camera-type eye development
GO:0045595 regulation of cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046427 positive regulation of JAK-STAT cascade
GO:0048469 cell maturation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048708 astrocyte differentiation
GO:0048712 negative regulation of astrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0050767 regulation of neurogenesis
GO:0051216 cartilage development
GO:0072049 comma-shaped body morphogenesis
GO:0072050 S-shaped body morphogenesis
GO:0072086 specification of loop of Henle identity
GO:0072282 metanephric nephron tubule morphogenesis
GO:0097150 neuronal stem cell maintenance
GO:2000737 negative regulation of stem cell differentiation
GO:2000974 negative regulation of pro-B cell differentiation
GO:2000981 negative regulation of inner ear receptor cell differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR003650 Orange
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR018352 Orange subgroup
PFAM PF07527
PF00010
PRINTS
PIRSF
SMART SM00353
SM00511
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A6H787
UniProt Splice Variant
Entrez Gene 787633
UniGene Bt.37917
RefSeq NP_001098937
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146153 DAAA02043208
GenPept AAI46154

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca