Version 5.4
Bos taurus Protein: HAGH
Summary
InnateDB Protein IDBP-686636.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAGH
Protein Name Hydroxyacylglutathione hydrolase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000026635
InnateDB Gene IDBG-634839 (HAGH)
Protein Structure
UniProt Annotation
Function Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid. {ECO:0000250}.
Subcellular Localization Isoform 1: Mitochondrion matrix {ECO:0000250}.Isoform 2: Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004416 hydroxyacylglutathione hydrolase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006750 glutathione biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001279 Beta-lactamase-like
IPR017782 Hydroxyacylglutathione hydrolase
PFAM PF00753
PRINTS
PIRSF PIRSF005457
SMART SM00849
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3B7M2
PhosphoSite PhosphoSite-
TrEMBL M5FMT6
UniProt Splice Variant
Entrez Gene 509274
UniGene
RefSeq NP_001030351
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC107545 GJ062847
GenPept AAI07546 DAA15563

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca