InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TP53INP2

Summary

InnateDB Protein

IDBP-68667.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TP53INP2

Protein Name

tumor protein p53 inducible nuclear protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000363942

InnateDB Gene

IDBG-68663 (TP53INP2)

Protein Structure

UniProt Annotation

Function

Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. {ECO:0000269PubMed:18030323, ECO:0000269PubMed:19056683, ECO:0000269PubMed:22470510}.

Subcellular Localization

Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006351	transcription, DNA-templated
GO:0010508	positive regulation of autophagy
GO:0045893	positive regulation of transcription, DNA-templated