Version 5.4
Bos taurus Protein: SKI
Summary
InnateDB Protein IDBP-686692.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SKI
Protein Name v-ski sarcoma viral oncogene homolog (avian)
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000053695
InnateDB Gene IDBG-634866 (SKI)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0046332 SMAD binding
GO:0046811 histone deacetylase inhibitor activity
GO:0070491 repressing transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001843 neural tube closure
GO:0002089 lens morphogenesis in camera-type eye
GO:0006351 transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0009948 anterior/posterior axis specification
GO:0010626 negative regulation of Schwann cell proliferation
GO:0014902 myotube differentiation
GO:0021772 olfactory bulb development
GO:0022011 myelination in peripheral nervous system
GO:0030326 embryonic limb morphogenesis
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031064 negative regulation of histone deacetylation
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0035019 somatic stem cell maintenance
GO:0042981 regulation of apoptotic process
GO:0043010 camera-type eye development
GO:0043388 positive regulation of DNA binding
GO:0043585 nose morphogenesis
GO:0045668 negative regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048147 negative regulation of fibroblast proliferation
GO:0048593 camera-type eye morphogenesis
GO:0048741 skeletal muscle fiber development
GO:0060021 palate development
GO:0060041 retina development in camera-type eye
GO:0060325 face morphogenesis
GO:0060349 bone morphogenesis
GO:0060395 SMAD protein signal transduction
GO:0070207 protein homotrimerization
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0016604 nuclear body
GO:0016605 PML body
GO:0017053 transcriptional repressor complex
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR003380 Transforming protein Ski
IPR009061 DNA binding domain, putative
IPR010919 SAND domain-like
IPR014890 c-SKI SMAD4-binding domain
PFAM PF02437
PF08782
PRINTS
PIRSF
SMART SM01046
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9N0Y8
UniProt Splice Variant
Entrez Gene 506127
UniGene Bt.51486
RefSeq XP_002694226
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF238294 DAAA02043220 DAAA02043221
GenPept AAF63483

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca