InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PRKCZ

Summary

InnateDB Protein

IDBP-686712.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKCZ

Protein Name

protein kinase C zeta type

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000018768

InnateDB Gene

IDBG-634912 (PRKCZ)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.

Predicted by orthology
Total	105 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0006468	protein phosphorylation
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0031333	negative regulation of protein complex assembly
GO:0032753	positive regulation of interleukin-4 production
GO:0035556	intracellular signal transduction
GO:0045630	positive regulation of T-helper 2 cell differentiation
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0072659	protein localization to plasma membrane
GO:1990138	neuron projection extension
GO:2000553	positive regulation of T-helper 2 cell cytokine production
GO:2000664	positive regulation of interleukin-5 secretion
GO:2000667	positive regulation of interleukin-13 secretion
GO:2001181	positive regulation of interleukin-10 secretion

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0005938	cell cortex
GO:0016324	apical plasma membrane
GO:0016363	nuclear matrix
GO:0035748	myelin sheath abaxonal region
GO:0043203	axon hillock
GO:0043234	protein complex
GO:0045179	apical cortex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000270 Phox/Bem1p
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR012233 Protein kinase C, zeta/iota
IPR017892 Protein kinase, C-terminal
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00564
PF00069
PF07714
PF00130
PF00433

PRINTS

PR00109
PR00008

PIRSF

PIRSF000554

SMART

SM00666
SM00133
SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A0JNH7

UniProt Splice Variant

Entrez Gene

286877

UniGene

Bt.15734

RefSeq

NP_001071301

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC126688 DAAA02043221 DAAA02043222

GenPept

AAI26689